Clinical Trials

E2108 - A Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients With Metastatic Breast Cancer

Most women with metastatic breast cancer have a recurrence after initially being diagnosed with early breast cancer (Stage I, II or III).  But did you know that for over 14,000 women in the US every year,  Stage IV is the first diagnosis they receive?  This means their breast cancer has already spread to distant parts of their body, like liver, lungs or bone, when it is found for the first time. 

The mainstay of treatment is anticancer medication, whether Stage IV breast cancer is diagnosed initially, or after a recurrence.  But there is one important unanswered question when it comes to surgery.  Will a woman whose breast cancer has already spread benefit from having her breast tumor removed, or can she safely be spared this surgery?  Now a clinical trial has been designed, and is enrolling at sites all over the country, that will answer this question. 

To read more about this trial, click on the E2108 Patient Summary  and Patient FAQ


 To learn about clinical trials and search for trials that may be available for you, here are four excellent websites:

  • Learning about Clinical Trials  The National Cancer Institute’s (NCI) introduction to clinical trials.
  • NCI Clinical Trials Search  Trials listed at the National Cancer Institute site overlap trial listings at
  •  User-friendly search site developed by the National Library of Medicine and the National Institutes of Health.  Companies developing drugs are required to list Phase II and III trials for their drugs here. 
  • See “Understanding Clinical Trials” at for good basic information on trials.

NCI Clinical Trials  Cooperative Group Program.   The Cooperative Groups design and conduct many of the studies done in advanced breast cancer after drugs are approved.